HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1,1,1-Trifluoro-8-phenyl-3,5,7-octatrien-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Methyl trifluoromethyl ketone | HCID 9871 | — |
| Reactant | 2,4-Pentadienal, 5-phenyl- | HCID 114651 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1,1,1-Trifluoro-8-phenyl-3,5,7-octatrien-2-one | HCID 86222662 | — |
Reaction Steps
1,1,1-Trifluoro-8-phenyl-3,5,7-octatrien-2-one is prepared as outlined in Scheme IIIA. 1,1,1-Trifluoro-8-phenyl-3,5,7-octatrien-2-one is prepared by reacting 5-phenyl-2,4-pentadienal in THF with an equal amount of acetic acid and piperidine followed by addition of 1,1,1-trifluoroacetone at room temperature under nitrogen.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842727B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-3c1b59cb34e04b828daea2d865bd638e |
| Source note | uspto-grants-2010_11 |