N-[2-(2-nitrophenyl)ethyl]acetamide → HCID 19593725, compound

HRID 1176269Notes

Reaction equation

HRID 1176269 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][CH2:11][NH:12][C:13](=[O:15])[CH3:14])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][CH2:11][NH:12][C:13](=[O:15])[CH3:14]

Participants

4

Reactant 1

HCID 2750518N-[2-(2-nitrophenyl)ethyl]acetamide

Product 1

HCID 19593725HCID 19593725, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 0.95 g of N-[2-(2-nitrophenyl)ethyl]acetamide in 30 ml of ethanol is hydrogenated in the presence of 0.112 g of 10% Pd/C at room temperature over 3.5 hours. The reaction mixture is clarified by filtration and the filtrate is concentrated by evaporation. The crude title compound is obtained as a light brown solid from the residue. Rf=0.50 (9:1 dichloromethane-methanol); Rt=1.86.

Workup

  1. filtrationThe reaction mixture is clarified by filtration
  2. concentrationthe filtrate is concentrated by evaporation

Sources & evidence

ORD record
ord-fdbc214fcf964759b7aca0fa321b43b0
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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