HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1176331Generated: October 28, 2026
Methyl iodide → 1-(4-Methoxybut-1-ynyl)-2-nitrobenzene
https://huagongshe.com/reaction/1176331
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 4-(2-Nitrophenyl)but-3-yn-1-ol | HCID 11745451 | — |
| Catalyst | Silver(II) oxide | HCID 92152 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(4-Methoxybut-1-ynyl)-2-nitrobenzene | HCID 68499034 | — |
Reaction Steps
A solution of 2.9 g of 4-(2-nitrophenyl)but-3-yn-1-ol in 750 ml of acetonitrile is admixed at room temperature with 17.5 g of silver oxide and 9.4 ml of methyl iodide and stirred at 50° C. over 70 hours. The reaction mixture is clarified by filtration and the filtrate is concentrated by evaporation. The title compound is obtained as a yellow oil from the residue by means of flash chromatography (SiO2 60F). Rf=0.34 (1:2 EtOAc-heptane); Rt=4.17.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07842688B2 |
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| Source dataset | uspto-grants-2010_11 |
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| ORD ID | ord-186d4a82c9e544948855a8c27cebc110 |
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| Source note | uspto-grants-2010_11 |
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