(2-Methoxyethyl)(methyl)amine → tert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-{3-[(2-methoxyethyl)methylcarbamoyl]benzyloxy}piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	(2-Methoxyethyl)(methyl)amine	HCID 300977	—
Reactant	HCID 86610001	HCID 86610001	—
Product	tert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-{3-[(2-methoxyethyl)methylcarbamoyl]benzyloxy}piperidine-1-carboxylate	HCID 68502919	—

Reaction Steps

Analogously to Example 127a, 0.355 g tert-butyl 3-(3-chlorocarbonylbenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate and 0.106 g of 2-methoxy-N-methylethylamine are reacted. The title compound is obtained as a colourless oil. Rf=0.10 (1:1 EtOAc-heptane); Rt=5.65.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07842688B2
Source dataset	uspto-grants-2010_11
ORD ID	ord-64d1e0d619dd4399b3eefa421889eb63
Source note	uspto-grants-2010_11