4-(2-hydroxyphenyl)-N-methylbutyramide → tert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[2-{2-(3-methylcarbamoylpropyl)phenoxy]ethoxy}piperidine-1-carboxylate

Participants

Reaction Steps

Analogously to Method G, 0.40 g of tert-butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[2-(toluene-4-sulphonyloxy)ethoxy]piperidine-1-carboxylate (Example 14b) and 0.23 g of 4-(2-hydroxyphenyl)-N-methylbutyramide are reacted. The title compound is obtained as a colourless resin. Rf=0.25 (200:20:1 dichloromethane-methanol-25% conc. ammonia); Rt=5.73.

Provenance & Evidence