HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 4-(2-hydroxyphenyl)-N-methylbutyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4,5-Dihydrobenzo[b]oxepin-2(3H)-one | HCID 10975795 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(2-hydroxyphenyl)-N-methylbutyramide | HCID 68501129 | — |
Reaction Steps
A solution of 1.0 g of 4,5-dihydro-3H-benzo[b]oxepin-2-one and 40 ml of 10% methylamine in isopropanol is heated in an autoclave at 100° C. over 16 hours. The reaction mixture is cooled to room temperature and concentrated by evaporation. The title compound is obtained as white crystals from the residue by means of flash chromatography (SiO2 60F). Rf=0.20 (4:1 EtOAc-heptane); Rt=2.66.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842688B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-46c0c9a46292460a8488aa84ee483bde |
| Source note | uspto-grants-2010_11 |