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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1176416Generated: November 1, 2026

3-Methoxypropanoyl chloride → 3-Methoxy-N-[2-methyl-5-(tetrahydropyran-2-yloxymethyl)phenyl]propionamide

https://huagongshe.com/reaction/1176416

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methoxypropanoyl chlorideHCID 2759728—
Reactant2-Methyl-5-(tetrahydropyran-2-yloxymethyl)phenylamineHCID 68503444—
Product3-Methoxy-N-[2-methyl-5-(tetrahydropyran-2-yloxymethyl)phenyl]propionamideHCID 68503311—

Reaction Steps

Analogously to Example 116b, 4.95 g of 2-methyl-5-(tetrahydropyran-2-yloxymethyl)phenylamine and 3.27 g of 3-methoxypropionyl chloride are reacted. The title compound is obtained as a white solid. Rf=0.33 (2:1 EtOAc-heptane); Rt=3.60.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07842688B2
Source datasetuspto-grants-2010_11
ORD IDord-2cb58927236d42df8efcd3d418eb85f2
Source noteuspto-grants-2010_11