HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Methyl-3-nitrobenzyloxy)tetrahydropyran → 2-Methyl-5-(tetrahydropyran-2-yloxymethyl)phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Methyl-3-nitrobenzyloxy)tetrahydropyran | HCID 68503488 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Methyl-5-(tetrahydropyran-2-yloxymethyl)phenylamine | HCID 68503444 | — |
Reaction Steps
The solution of 12.3 g of 2-(4-methyl-3-nitrobenzyloxy)tetrahydropyran in 150 ml of ethanol is hydrogenated in the presence of 1.25 g of 10% Pd/C over 24 hours. The reaction mixture is filtered and the filtrate is concentrated by evaporation. The title compound is obtained as a colourless oil from the residue by means of flash chromatography (SiO2 60F). Rf=0.19 (1:2 EtOAc-heptane); Rt=2.72.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842688B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-0ebde2d9657f4b20ad2799b80a265210 |
| Source note | uspto-grants-2010_11 |