3-Methoxypropanoyl chloride → HCID 68571803, compound

HRID 1176419Notes

Reaction equation

[CH:1]([NH:4][C:5]1[CH:6]=[C:7]([CH:43]=[CH:44][CH:45]=1)[CH2:8][O:9][CH:10]1[CH:15]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][O:26][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[O:34][CH3:35])=[CH:18][CH:17]=2)[CH2:14][CH2:13][N:12]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:11]1)([CH3:3])[CH3:2].[CH3:46][O:47][CH2:48][CH2:49][C:50](Cl)=[O:51]>>[CH:1]([N:4]([C:50](=[O:51])[CH2:49][CH2:48][O:47][CH3:46])[C:5]1[CH:6]=[C:7]([CH:43]=[CH:44][CH:45]=1)[CH2:8][O:9][CH:10]1[CH:15]([C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][CH2:25][O:26][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[O:34][CH3:35])=[CH:20][CH:21]=2)[CH2:14][CH2:13][N:12]([C:36]([O:38][C:39]([CH3:40])([CH3:42])[CH3:41])=[O:37])[CH2:11]1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 27597283-Methoxypropanoyl chloride

HCID 68499040Tert-butyl 3-(3-isopropylaminobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate

Product 1

HCID 68571803HCID 68571803, compound

Procedure

Analogously to Example 116b, 0.400 g of tert-butyl 3-(3-isopropylaminobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate and 0.270 g of 3-methoxypropionyl chloride are reacted. The title compound is obtained as a colourless oil. Rf=0.27 (1:1 EtOAc-heptane); Rt=5.97.

Sources & evidence

ORD record: ord-b52bffc69fd94d5bb47d4435b81b7f67
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842688B2

Reaction notes

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