HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Bromopropoxy)-3-methoxybenzene → tert-Butyl 3-hydroxy-4-{4-[3-(3-methoxyphenoxy)propoxy]phenyl}piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Bromopropoxy)-3-methoxybenzene | HCID 10955816 | — |
| Reactant | (3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate | HCID 21713087 | — |
| Product | tert-Butyl 3-hydroxy-4-{4-[3-(3-methoxyphenoxy)propoxy]phenyl}piperidine-1-carboxylate | HCID 53958248 | — |
Reaction Steps
Analogously to Method I, 0.750 g of tert-butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.808 g of 1-(3-bromopropoxy)-3-methoxybenzene are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.30 (1:2 EtOAc-heptane); Rt=5.18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842688B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-1e04a2bfc4034fc4950ab77ea91fd71a |
| Source note | uspto-grants-2010_11 |