HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(3-Bromopropoxy)-3-chlorobenzene → Tert-butyl 4-{4-[3-(3-chlorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(3-Bromopropoxy)-3-chlorobenzene | HCID 2734929 | — |
| Edukt | (3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate | HCID 21713087 | — |
| Produkt | Tert-butyl 4-{4-[3-(3-chlorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate | HCID 68505679 | — |
Reaktionsschritte
Analogously to Method I, 0.750 g of tert-butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.832 g of 1-(3-bromopropoxy)-3-chlorobenzene are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.30 (1:2 EtOAc-heptane); Rt=5.55.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07842688B2 |
| Quelldatensatz | uspto-grants-2010_11 |
| ORD ID | ord-0b9302ee530c4f8f9d387929bd139c88 |
| Quellennotiz | uspto-grants-2010_11 |