56219-51-3 → HCID 68499485, compound

HRID 1176471Notes

Reaction equation

HRID 1176471 reaction equation
[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:3]1.Br[CH2:23][CH2:24][CH2:25][O:26][C:27]1[CH:35]=[CH:34][C:30]2[O:31][CH2:32][O:33][C:29]=2[CH:28]=1>>[O:31]1[C:30]2[CH:34]=[CH:35][C:27]([O:26][CH2:25][CH2:24][CH2:23][O:14][C:11]3[CH:10]=[CH:9][C:8]([CH:7]4[CH2:6][CH2:5][N:4]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:3][CH:2]4[OH:1])=[CH:13][CH:12]=3)=[CH:28][C:29]=2[O:33][CH2:32]1

Participants

3

Reactant 2

HCID 1091221656219-51-3HCID 21713087(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate

Product 1

HCID 68499485HCID 68499485, compound

Procedure

Analogously to Method I, 0.750 g of tert-butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.859 g of 5-(3-bromopropoxy)benzo[1,3]dioxole are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.10 (1:2 EtOAc-heptane); Rt=4.96.

Sources & evidence

ORD record
ord-21c83b1d5ead411b94705d277404e69a
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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