HCID 9972828, compound → HCID 68503008, compound

HRID 1176491Notes

Reaction equation

HRID 1176491 reaction equation
[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:3]1.C1(C)C=CC(S(O[CH2:32][CH2:33][CH2:34][O:35][CH:36]2[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]2)(=O)=O)=CC=1>>[CH:36]1([O:35][CH2:34][CH2:33][CH2:32][O:14][C:11]2[CH:10]=[CH:9][C:8]([CH:7]3[CH2:6][CH2:5][N:4]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:3][CH:2]3[OH:1])=[CH:13][CH:12]=2)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1

Participants

3

Reactant 2

HCID 9972828HCID 9972828, compoundHCID 21713087(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate

Product 1

HCID 68503008HCID 68503008, compound

Procedure

Analogously to Method I, 0.795 g of tert-butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 1.07 g of 3-cyclohexyloxypropyl toluene-4-sulphonate are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.39 (1:1 EtOAc-heptane); Rt=5.43.

Sources & evidence

ORD record
ord-a1f842ee01004c1eb0d00d5999411778
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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