Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | (2S)-2-(phenoxymethyl)oxirane | HCID 1534345 | — |
| Reactant | HCID 68500605 | HCID 68500605 | — |
| Product | HCID 68501142 | HCID 68501142 | — |
Reaction Steps
The mixture of 0.280 g of benzyl 4-(4-hydroxyphenyl)-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate, 0.152 g of 2(S)-phenoxymethyloxirane and 0.0015 g of caesium fluoride is stirred at 130° C. over 3 hours. The reaction mixture is cooled and the title compound is obtained as a colourless oil by means of flash chromatography (SiO2 60F). Rf=0.13 (1:1 EtOAc-heptane); Rt=5.14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07842688B2 |
|---|
| Source dataset | uspto-grants-2010_11 |
|---|
| ORD ID | ord-0281f0d5b4814ea8aa2bf5da87948e65 |
|---|
| Source note | uspto-grants-2010_11 |
|---|
