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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1176505Generated: November 2, 2026

HCID 68500610, compound → HCID 68501828, compound

https://huagongshe.com/reaction/1176505

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 68500610HCID 68500610—
Reactant6-chloromethyl-4-(2-triisopropylsilanyloxyethyl)-4H-benzo[1,4]oxazin-3-oneHCID 68504773—
ProductHCID 68501828HCID 68501828—

Reaction Steps

Analogously to Method D, 1.34 g of benzyl 4-{4-[3-(2,5-difluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate and 1.43 g of 6-chloromethyl-4-(2-triisopropylsilanyloxyethyl)-4H-benzo[1,4]oxazin-3-one are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.55 (1:1 EtOAc-heptane); Rt=7.03.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07842688B2
Source datasetuspto-grants-2010_11
ORD IDord-c14efcc644ae49208d58b0ebce1bef72
Source noteuspto-grants-2010_11