HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-tert-Butyl 3-(tosyloxy)pyrrolidine-1-carboxylate → benzyl 4-[4-(1-tert-butoxycarbonylpyrrolidin-3(S)-yloxy)phenyl]-3-hydroxypiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-tert-Butyl 3-(tosyloxy)pyrrolidine-1-carboxylate | HCID 23560883 | — |
| Reactant | Benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidinecarboxylate | HCID 68500730 | — |
| Product | benzyl 4-[4-(1-tert-butoxycarbonylpyrrolidin-3(S)-yloxy)phenyl]-3-hydroxypiperidine-1-carboxylate | HCID 68499656 | — |
Reaction Steps
Analogously to Method I, 0.665 g of benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.822 g of tert-butyl 3(R)-(toluene-4-sulphonyloxy)pyrrolidine-1-carboxylate are reacted. The title compound is obtained as a white foam. Rf=0.14 (1:1 EtOAc-heptane). Rt=4.91.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842688B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-bf2f0a0e111c452ab122fb48f1f3683f |
| Source note | uspto-grants-2010_11 |