Tert-butyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy) propoxy]phenyl}piperidine-1-carboxylate → HCID 68505303, compound

HRID 1176532Notes

Reaction equation

HRID 1176532 reaction equation
[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:26][CH3:27])=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:3]1.Cl[CH2:36][C:37]1[CH:38]=[CH:39][CH:40]=[C:41]2[C:46]=1[N:45]([CH2:47][O:48][CH2:49][CH2:50][Si:51]([CH3:54])([CH3:53])[CH3:52])[C:44](=[O:55])[CH2:43][C:42]2([CH3:57])[CH3:56]>>[CH3:56][C:42]1([CH3:57])[C:41]2[C:46](=[C:37]([CH2:36][O:1][CH:2]3[CH:7]([C:8]4[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=5[O:26][CH3:27])=[CH:10][CH:9]=4)[CH2:6][CH2:5][N:4]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:3]3)[CH:38]=[CH:39][CH:40]=2)[N:45]([CH2:47][O:48][CH2:49][CH2:50][Si:51]([CH3:52])([CH3:54])[CH3:53])[C:44](=[O:55])[CH2:43]1

Participants

3

Reactant 2

HCID 15546933Tert-butyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy) propoxy]phenyl}piperidine-1-carboxylateHCID 68501566HCID 68501566, compound

Product 1

HCID 68505303HCID 68505303, compound

Procedure

Analogously to Method D, 0.28 g of tert-butyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate and 0.21 g of 8-chloromethyl-4,4-dimethyl-1-(2-trimethylsilanylethoxymethyl)-3,4-dihydro-1H-quinolin-2-one are reacted. The title compound is obtained as a yellowish oil. Rf=0.33 (1:2 EtOAc-heptane); Rt=6.81.

Sources & evidence

ORD record
ord-d5ecb2a9bf654a6abfffb372fab0502b
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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