Bromoacetonitrile → HCID 26597022, compound

HRID 1176552Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].Br[CH2:11][C:12]#[N:13]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH2:11][C:12]#[N:13]

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 949522,5-Difluorophenol

Product 1

HCID 26597022HCID 26597022, compound

Procedure

Analogously to Method F, 2.0 g of 2,5-difluorophenol and 2.1 ml of bromoacetonitrile are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.52 (1:2 EtOAc-heptane); Rt=3.86.

Sources & evidence

ORD record: ord-b0e38114f1464dbf83508bc6d9a92cad
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842688B2

Reaction notes

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