HRID1176572

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(OCc1ccccc1)N1CCC(c2ccc(O)cc2)C(O)C1

HCID68500730

未命名化合物

结构：Cc1ccc(S(=O)(=O)OCC(F)(F)COc2ccccc2)cc1

HCID86610021

未命名化合物

PRODUCTS

生成物

结构：O=C(OCc1ccccc1)N1CCC(c2ccc(OCC(F)(F)COc3ccccc3)cc2)C(O)C1

HCID68500743

未命名化合物

PROCEDURE

实验过程

Analogously to Method G, 0.350 g of 2,2-difluoro-3-phenoxypropyl toluene-4-sulphonate and 0.452 g of benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate are reacted. The title compound is obtained as a yellow oil. Rf=0.25 (1:1 EtOAc-heptane); Rt=5.11.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-856bfbe38095435f813ede762cb11d82
来源数据集: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07842688B2
来源说明: uspto-grants-2010_11

反应 SMILES

C1(C)C=CC(S(O[CH2:11][C:12]([F:22])([F:21])[CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=O)=O)=CC=1.[OH:24][CH:25]1[CH:30]([C:31]2[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][CH:32]=2)[CH2:29][CH2:28][N:27]([C:38]([O:40][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)=[O:39])[CH2:26]1>>[F:21][C:12]([F:22])([CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:11][O:37][C:34]1[CH:33]=[CH:32][C:31]([CH:30]2[CH2:29][CH2:28][N:27]([C:38]([O:40][CH2:41][C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=3)=[O:39])[CH2:26][CH:25]2[OH:24])=[CH:36][CH:35]=1