Ethylene glycol ditosylate → HCID 86610024, compound

HRID 1176586Notes

Reaction equation

OC1C=CC([CH:8]2[CH:13]([O:14][CH2:15][C:16]3[CH:17]=[CH:18][C:19]4[O:24][CH2:23][C:22](=[O:25])[N:21]([CH2:26][CH2:27][CH2:28][O:29][CH3:30])[C:20]=4[CH:31]=3)[CH2:12][CH2:11][CH2:10][N:9]2[C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])=CC=1.C1(C)C=CC(S([O:51][CH2:52][CH2:53][O:54][S:55]([C:58]2[CH:63]=[CH:62][C:61]([CH3:64])=[CH:60][CH:59]=2)(=[O:57])=[O:56])(=O)=O)=CC=1>>[CH3:30][O:29][CH2:28][CH2:27][CH2:26][N:21]1[C:20]2[CH:31]=[C:16]([CH2:15][O:14][CH:13]3[CH:12]([C:16]4[CH:17]=[CH:18][C:19]([O:51][CH2:52][CH2:53][O:54][S:55]([C:58]5[CH:59]=[CH:60][C:61]([CH3:64])=[CH:62][CH:63]=5)(=[O:56])=[O:57])=[CH:20][CH:31]=4)[CH2:11][CH2:10][N:9]([C:32]([O:34][CH2:35][C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)=[O:33])[CH2:8]3)[CH:17]=[CH:18][C:19]=2[O:24][CH2:23][C:22]1=[O:25]

Participants

Reactant 2

HCID 228289Ethylene glycol ditosylate

HCID 68504285HCID 68504285, compound

Product 1

HCID 86610024HCID 86610024, compound

Procedure

Analogously to Method I, 0.417 g of benzyl 4-hydroxyphenyl-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidinecarboxylate and 0.984 g of ethylene di(p-toluenesulphonate) are reacted. The title compound is obtained as a colourless oil. Rf=0.31 (2:1 EtOAc-heptane); Rt=5.35.

Sources & evidence

ORD record: ord-1adbd81fd39c46bf9f74f8ecc125dd32
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842688B2

Reaction notes

Loading…