HCID 68501506, compound → HCID 68499530, compound

HRID 1176632Notes

Reaction equation

HRID 1176632 reaction equation
[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[CH2:3]1.Cl[CH2:27][C:28]1[CH:29]=[CH:30][C:31]2[O:36][C:35]([CH3:38])([CH3:37])[C:34](=[O:39])[N:33]([CH2:40][CH2:41][CH2:42][O:43][CH3:44])[C:32]=2[CH:45]=1>>[CH3:15][O:14][C:11]1[CH:10]=[CH:9][C:8]([CH:7]2[CH2:6][CH2:5][N:4]([C:16]([O:18][CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[O:17])[CH2:3][CH:2]2[O:1][CH2:27][C:28]2[CH:29]=[CH:30][C:31]3[O:36][C:35]([CH3:38])([CH3:37])[C:34](=[O:39])[N:33]([CH2:40][CH2:41][CH2:42][O:43][CH3:44])[C:32]=3[CH:45]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 68501506HCID 68501506, compoundHCID 68502100HCID 68502100, compound

Product 1

HCID 68499530HCID 68499530, compound

Procedure

Analogously to Method D, 0.500 g of benzyl 3-hydroxy-4-(4-methoxyphenyl)piperidine-1-carboxylate and 0.505 g of 6-chloromethyl-4-(3-methoxypropyl)-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one are reacted. The title compound is obtained as an orange oil. Rf=0.17 (1:1 EtOAc-heptane); Rt=5.51.

Sources & evidence

ORD record
ord-42fe049d79854b0e8eca0439e370cf43
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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