1-Chloro-4-(chloromethyl)benzene → HCID 11717881, compound

HRID 1176661Notes

Reaction equation

HRID 1176661 reaction equation
[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][N:3]2[C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]([CH2:16][C:15]3[CH:18]=[CH:19][C:12]([Cl:11])=[CH:13][CH:14]=3)[C:2]2=[NH:1])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 136242-Aminobenzimidazole

Product 1

HCID 11717881HCID 11717881, compound

Procedure

The title compound was prepared from 2-aminobenzimidazole and 4-chlorobenzyl chloride by Procedure A. The product was isolated by preparative LCMS to give the title compound as the free base (white solid, mp 185-187° C.). MS(ES+) m/z 382 (M+, 100). 1NMR (DMSO-d6) δ 5.08 (br s, 4H), 5.76 (s, 1H), 6.80-6.90 (m, 4H), 7.25-7.42 (m, 8H).

Workup

  1. customThe product was isolated by preparative LCMS

Sources & evidence

ORD record
ord-18a20fc5f35947de9fa3ceaf8d71361f
Source dataset
uspto-grants-2010_11
Patent number
US07842817B2

Reaction notes

Loading…