4-(Trifluoromethyl)aniline → HCID 11582157, compound

Participants

Reaction Steps

The title compound was prepared by Procedure B in two steps from 2-chloro-benzimidazole, 3,4-difluorobenzyl bromide and 4-trifluoromethylaniline. The product was isolated by preparative LCMS and recrystallization (EtOAc/Et2O) to give the title compound as the free base (off-white solid, mp 167-170° C.). MS(ES+) m/z 404 ([M+1]+, 100). 1NMR (DMSO-d6) δ 5.55 (s, 2H), 6.90-6.97 (m, 1H), 7.02-7.13 (m, 2H), 7.25-7.50 (m, 4H), 7.65-7.71 (m, 2H), 8.04-8.12 (m, 2H), 9.55 (s, 1H).

Provenance & Evidence