2-Aminobenzimidazole → HCID 11523864, compound

HRID 1176671Notes

Reaction equation

[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([F:20])[CH:19]=1)[CH2:15]Br>>[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([F:20])[CH:19]=1)[CH2:15][N:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]([CH2:15][C:14]2[CH:13]=[C:12]([F:11])[CH:19]=[C:18]([F:20])[CH:17]=2)[C:2]1=[NH:1]

Participants

Reactant 2

HCID 136242-Aminobenzimidazole

HCID 5188963,5-Difluorobenzyl bromide

Product 1

HCID 11523864HCID 11523864, compound

Procedure

The title compound was prepared from 2-aminobenzimidazole and 3,5-difluorobenzyl bromide by Procedure A. The title product was isolated by filtration and washed with acetonitrile and water to give the title compound as the free base (white solid, mp 144-145° C.). MS(ES+) m/z 386 ([M+1]+, 100).

Sources & evidence

ORD record: ord-3ec270f327dc4dbfb9f6be62fdbd4595
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842817B2

Reaction notes

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