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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1176773Generated: October 31, 2026

Methyl 5-(chloromethyl)-2-furoate → 5-[[4-(4-methylphenyl)phenoxy]methyl]furan-2-carboxylic Acid

https://huagongshe.com/reaction/1176773

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 5-(chloromethyl)-2-furoateHCID 75065—
Reactant4-(4-Methylphenyl)phenolHCID 1382789—
Product5-[[4-(4-methylphenyl)phenoxy]methyl]furan-2-carboxylic AcidHCID 7138853—

Reaction Steps

5-(4′-Methyl-biphenyl-4-yloxymethyl)-furan-2-carboxylic acid was prepared using general procedure A from 4′-methyl-biphenyl-4-ol (purchased from Maybridge plc, Tintagel, Cornwall, UK or from Intermediate 5) and 5-chloromethylfuran-2-carboxylic acid methyl ester (available from Aldrich, Milwaukee, Wis., or from Maybridge plc, Tintagel, UK). Yield: 47 mg. Mass spectrum (ES) MH+=309.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07842825B2
Source datasetuspto-grants-2010_11
ORD IDord-be5382658eec45aba6bf3c66f6116c1e
Source noteuspto-grants-2010_11