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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1176787Generated: October 26, 2026

4-Hydroxybiphenyl → 6-(Biphenyl-4-yloxymethyl)-pyridine-2-carboxylic acid

https://huagongshe.com/reaction/1176787

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-HydroxybiphenylHCID 7103—
ReactantMethyl 6-(bromomethyl)pyridine-2-carboxylateHCID 21471714—
Product6-(Biphenyl-4-yloxymethyl)-pyridine-2-carboxylic acidHCID 11472238—

Reaction Steps

6-(Biphenyl-4-yloxymethyl)-pyridine-2-carboxylic acid was prepared using general procedure B from 4-phenylphenol (available from Aldrich, Milwaukee, Wis.) and 6-bromomethyl-pyridine-2-carboxylic acid methyl ester (Intermediate 2). Yield: 68 mg. Mass spectrum (ES) MH+=306.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07842825B2
Source datasetuspto-grants-2010_11
ORD IDord-4c6178779636493aa0f14f48cea118bd
Source noteuspto-grants-2010_11