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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1176788Generated: November 2, 2026

2-Chloro-4-Phenylphenol → 2-(3-Chloro-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid

https://huagongshe.com/reaction/1176788

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4-PhenylphenolHCID 7074—
ReactantEthyl 2-(bromomethyl)-1,3-thiazole-4-carboxylateHCID 11043146—
Product2-(3-Chloro-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acidHCID 11393835—

Reaction Steps

2-(3-Chloro-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid was prepared using general procedure B from 2-chloro-4-phenylphenol (available from TCI America, Portland, Oreg.) and 2-bromomethyl-thiazole-4-carboxylic acid ethyl ester (Intermediate 3). Yield: 82 mg. Mass spectrum (ES) MH+=346.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07842825B2
Source datasetuspto-grants-2010_11
ORD IDord-e147eb4bd32c4db4b55eb42f4ed2dc16
Source noteuspto-grants-2010_11