4'-Chloro-4-biphenylol → 2-(4'-Chloro-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid

HRID 1176792Notes

Reaction equation

HRID 1176792 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C([O:17][C:18]([C:20]1[N:21]=[C:22]([CH2:25]Br)[S:23][CH:24]=1)=[O:19])C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:25][C:22]3[S:23][CH:24]=[C:20]([C:18]([OH:19])=[O:17])[N:21]=3)=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 915894'-Chloro-4-biphenylolHCID 11043146Ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate2×

Product 1

HCID 114279512-(4'-Chloro-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid

Procedure

2-(4′-Chloro-biphenyl-4-yloxymethyl)-thiazole-4-carboxylic acid was prepared using general procedure B from 4-chloro-4′-hydroxybiphenyl (available from TCI America, Portland, Oreg.) and 2-bromomethyl-thiazole-4-carboxylic acid ethyl ester (Intermediate 3). Yield: 82 mg. Mass spectrum (ES) MH+=346.

Sources & evidence

ORD record
ord-6c076c7f38d74293b0486c4d9269ea40
Source dataset
uspto-grants-2010_11
Patent number
US07842825B2

Reaction notes

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