HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1176810Generated: November 3, 2026
Ammonia → Ethyl (2Z)-3-amino-2-cyano-4-ethyl-2-hexenoate
https://huagongshe.com/reaction/1176810
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl 2-cyano-3-methoxy-4-ethyl-2-hexenoate | HCID 72326554 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl (2Z)-3-amino-2-cyano-4-ethyl-2-hexenoate | HCID 11564730 | — |
Reaction Steps
At 10° C., 52 g (0.23 mol) of ethyl 2-cyano-3-methoxy-4-ethyl-2-hexenoate were initially charged in THF, and 20 g (0.3 mol) of 25% strength ammonia solution were added. After 2 h of stirring at 25° C., the solution was concentrated, the residue was taken up in n-hexane/diisopropyl ether (1:1) and the precipitate was filtered off with suction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07842832B2 |
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| Source dataset | uspto-grants-2010_11 |
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| ORD ID | ord-184c1f0b375c439da72cf900d2fb7f73 |
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| Source note | uspto-grants-2010_11 |
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