HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Anisidine → 7-Methoxy-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | Chlorosulfonyl isocyanate | HCID 70918 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | 7-Methoxy-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide | HCID 12528490 | — |
Reaction Steps
Commercially available 4-methoxyaniline can be treated with chlorosulfonyl isocyanate followed by aluminum chloride to give the corresponding 7-methoxy-1,1-dioxo-1,4-dihydro-2H-1λ6-benzo[1,2,4]thiadiazin-3-one. Opening of the cyclic urea with a strong acid (e.g., sulfuric acid) gives the desired 2-amino-5-methoxy-benzenesulfonamide intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842838B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-8c381e5f498348c58cfd587d347bcddc |
| Source note | uspto-grants-2010_11 |