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HRID1177104

反应详情

EQUATION

反应方程式

HRID 1177104 的结构方程式

REACTANTS

反应物

3
结构：COC(=O)c1cc(O)c2c(c1)OC(C)(C)C2
HCID25067323

Methyl 4-hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-6-carboxylate

C12H14O4

结构：CC(C)(C)OC(=O)c1ccc(Br)cc1F
HCID46738774

tert-Butyl 4-bromo-2-fluorobenzoate

C11H12BrFO2

结构：COC(=O)c1cc(Oc2ccc(C(=O)N3CCC3)cc2)c2c(c1)OC(C)(C)C2
HCID59560251

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1cc(Oc2ccc(C(=O)OC(C)(C)C)c(F)c2)c2c(c1)OC(C)(C)C2
HCID59559856

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a similar manner as described for Intermediate 35b, from 4-bromo-2-fluoro-benzoic acid tert-butyl ester and 4-hydroxy-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid methyl ester (3e). 1H NMR (400 MHz, CDCl3) δ 7.86 (t, J=8.59 Hz, 1 H) 7.25-7.31 (m, 1 H) 7.24 (s, 1 H) 6.74 (dd, J=8.84, 2.02 Hz, 1 H) 6.65 (dd, J=11.87, 2.27 Hz, 1 H) 3.88 (s, 3 H) 2.87 (s, 2 H) 1.59 (s, 9 H) 1.48 (s, 6 H); LCMS for C23H25FO6 m/z 439.00 (M+Na)+.