HRID1177128

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21

HCID159087

Triacetoxyperiodinane

C13H13IO8

结构：CN(C)C(=O)c1ccc(Oc2cc(C(=O)Nc3ccc(CO)cn3)cc3c2CC(C)(C)O3)cc1F

HCID59560119

未命名化合物

PRODUCTS

生成物

HCID59560038

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度: 0 °C

PROCEDURE

实验过程

To a solution of 4-(4-Dimethylcarbamoyl-3-fluoro-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (5-hydroxymethyl-pyridin-2-yl)-amide (145) (88 mg, 0.18 mmol) in 3 mL CH2Cl2 was added Dess-Martin periodinane (93.4 mg, 0.22 mmol) at 0° C. The mixture was stirred at 0° C. for 1.5 hr. The reaction was quenched with water, extracted with 3×CHCl3. The combined organic layer was dried with Na2SO4 and concentrated. The resulting oil was taken into the next step without further purification. LCMS for C26H24FN3O5 m/z 478.20 (M+H+).

WORKUP

后处理

customThe reaction was quenched with water
extractionextracted with 3×CHCl3
dry with materialThe combined organic layer was dried with Na2SO4
concentrationconcentrated
customThe resulting oil was taken into the next step without further purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8bba4ffec5a042a29fb899b6ad957637
来源数据集: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07842713B2
来源说明: uspto-grants-2010_11

反应 SMILES

[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]([C:12]2[CH:22]=[C:21]([O:23][C:24]3[CH:29]=[CH:28][C:27]([C:30](=[O:34])[N:31]([CH3:33])[CH3:32])=[C:26]([F:35])[CH:25]=3)[C:15]3[CH2:16][C:17]([CH3:20])([CH3:19])[O:18][C:14]=3[CH:13]=2)=[O:11])=[N:7][CH:8]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl>[CH:2]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]([C:12]2[CH:22]=[C:21]([O:23][C:24]3[CH:29]=[CH:28][C:27]([C:30](=[O:34])[N:31]([CH3:33])[CH3:32])=[C:26]([F:35])[CH:25]=3)[C:15]3[CH2:16][C:17]([CH3:20])([CH3:19])[O:18][C:14]=3[CH:13]=2)=[O:11])=[N:7][CH:8]=1)=[O:1]