4-(4-Cyano-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide → HCID 178480463, compound

HRID 1177170Notes

Reaction equation

HRID 1177170 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[CH:20]=[C:19]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[NH:31])[NH:29][OH:30])=[C:24](F)[CH:23]=3)[C:13]3[CH2:14][C:15]([CH3:18])([CH3:17])[O:16][C:12]=3[CH:11]=2)=[O:9])=[N:3]1.CN1C=CC(NC(C2C=C(OC3C=CC(C#N)=CC=3)C3CC(C)(C)OC=3C=2)=O)=N1>>[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[CH:20]=[C:19]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[NH:31])[NH:29][OH:30])=[CH:24][CH:23]=3)[C:13]3[CH2:14][C:15]([CH3:18])([CH3:17])[O:16][C:12]=3[CH:11]=2)=[O:9])=[N:3]1

Participants

3

Reactant 2

HCID 667557924-(4-Cyano-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amideHCID 178480465HCID 178480465, compound

Product 1

HCID 178480463HCID 178480463, compound

Procedure

The title compound was prepared in a similar manner as described for Intermediate 185a, from 4-(4-cyano-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide (187b) (212 mg, 0.321 mmol) and used without further purification for the next step.

Workup

  1. customused without further purification for the next step

Sources & evidence

ORD record
ord-a696d4609b1b4166ac25f06e0b193a19
Source dataset
uspto-grants-2010_11
Patent number
US07842713B2

Reaction notes

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