4-(4-Cyano-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (2-methyl-2H-[1,2,3]triazol-4-yl)-amide → HCID 178481871, compound

HRID 1177172Notes

Reaction equation

HRID 1177172 reaction equation
C[N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[CH:20]=[C:19]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[NH:31])[NH:29][OH:30])=[C:24](F)[CH:23]=3)[C:13]3[CH2:14][C:15]([CH3:18])([CH3:17])[O:16][C:12]=3[CH:11]=2)=[O:9])=[N:3]1.C[N:34]1N=C(NC(C2C=C(OC3C=CC(C#N)=CC=3)C3CC(C)(C)OC=3C=2)=O)C=N1>>[CH3:6][N:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[CH:20]=[C:19]([O:21][C:22]3[CH:23]=[CH:24][C:25]([C:28](=[NH:31])[NH:29][OH:30])=[CH:26][CH:27]=3)[C:13]3[CH2:14][C:15]([CH3:17])([CH3:18])[O:16][C:12]=3[CH:11]=2)=[O:9])[CH:5]=[N:34]1

Participants

3

Reactant 2

HCID 667557244-(4-Cyano-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (2-methyl-2H-[1,2,3]triazol-4-yl)-amideHCID 178480465HCID 178480465, compound

Product 1

HCID 178481871HCID 178481871, compound

Procedure

The title compound was prepared in a similar manner as described for Intermediate 185a, from 4-(4-cyano-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (2-methyl-2H-[1,2,3]triazol-4-yl)-amide (188a) (130 mg, 0.334 mmol) and used without further purification for the next step.

Workup

  1. customused without further purification for the next step

Sources & evidence

ORD record
ord-7cf13bd60baf466789ece94e57d2a8bf
Source dataset
uspto-grants-2010_11
Patent number
US07842713B2

Reaction notes

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