1-Methyl-3-aminopyrazole → HCID 59560097, compound

HRID 1177240Notes

Reaction equation

HRID 1177240 reaction equation
C([O:5][C:6]([C:8]1[CH:19]=[C:18]([O:20][C:21]2[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[C:23]([F:31])[CH:22]=2)[C:11]2[CH2:12][C:13]([CH2:16][OH:17])([CH3:15])[O:14][C:10]=2[CH:9]=1)=O)(C)(C)C.[NH2:32][C:33]1[CH:37]=[CH:36][N:35]([CH3:38])[N:34]=1>>[CH3:38][N:35]1[CH:36]=[CH:37][C:33]([NH:32][C:6]([C:8]2[CH:19]=[C:18]([O:20][C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[C:23]([F:31])[CH:22]=3)[C:11]3[CH2:12][C:13]([CH2:16][OH:17])([CH3:15])[O:14][C:10]=3[CH:9]=2)=[O:5])=[N:34]1

Participants

3

Reactant 2

HCID 1372541-Methyl-3-aminopyrazoleHCID 59560110HCID 59560110, compound

Product 1

HCID 59560097HCID 59560097, compound

Procedure

The title compound was prepared in a similar manner as described for Example 200, from 4-(3-fluoro-4-methanesulfonyl-phenoxy)-2-hydroxymethyl-2-methyl-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl ester (232a) and 3-amino-1-methyl-pyrazole. 1H NMR (400 MHz, CDCl3) δ 8.36 (s, 1 H) 7.80-7.99 (m, 1 H) 7.26-7.32 (m, 1 H) 7.11 (dd, J=17.05, 1.39 Hz, 2 H) 6.73-6.92 (m, 3 H) 3.82 (s, 3 H) 3.75 (d, J=5.56 Hz, 1 H) 3.63 (d, J=7.58 Hz, 1 H) 3.23 (s, 3 H) 2.81 (d, J=16.17 Hz, 1 H) 2.04 (d, J=1.77 Hz, 1 H) 1.47 (s, 3 H); LCMS for C22H22FN3O6S m/z 476.00 (M+H+).

Sources & evidence

ORD record
ord-2f3b12713fc64003809bfe6fbcedfa39
Source dataset
uspto-grants-2010_11
Patent number
US07842713B2

Reaction notes

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