1-Methyl-3-aminopyrazole → HCID 59560001, compound

HRID 1177243Notes

Reaction equation

HRID 1177243 reaction equation
C(O[C:6]([C:8]1[CH:20]=[C:19]([O:21][C:22]2[CH:27]=[CH:26][C:25]([S:28]([CH3:31])(=[O:30])=[O:29])=[C:24]([F:32])[CH:23]=2)[C:11]2[CH2:12][C:13]([CH2:16][O:17][CH3:18])([CH3:15])[O:14][C:10]=2[CH:9]=1)=[O:7])(C)(C)C.[NH2:33][C:34]1[CH:38]=[CH:37][N:36]([CH3:39])[N:35]=1>>[CH3:39][N:36]1[CH:37]=[CH:38][C:34]([NH:33][C:6]([C:8]2[CH:20]=[C:19]([O:21][C:22]3[CH:27]=[CH:26][C:25]([S:28]([CH3:31])(=[O:29])=[O:30])=[C:24]([F:32])[CH:23]=3)[C:11]3[CH2:12][C:13]([CH2:16][O:17][CH3:18])([CH3:15])[O:14][C:10]=3[CH:9]=2)=[O:7])=[N:35]1

Participants

3

Reactant 2

HCID 1372541-Methyl-3-aminopyrazoleHCID 59560274HCID 59560274, compound

Product 1

HCID 59560001HCID 59560001, compound

Procedure

The title compound was prepared in a similar manner as described for Example 200, from 4-(3-fluoro-4-methanesulfonyl-phenoxy)-2-methoxymethyl-2-methyl-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl ester (237a) and 3-amino-1-methyl-pyrazole. 1H NMR (300 MHz, CDCl3) δ 8.37 (s, 1 H) 7.92 (t, J=8.38 Hz, 1 H) 7.29 (d, J=2.26 Hz, 1 H) 7.12 (d, J=1.13 Hz, 1 H) 7.08 (d, J=1.13 Hz, 1 H) 6.88 (dd, J=8.76, 2.35 Hz, 1 H) 6.76-6.84 (m, 2 H) 3.81 (s, 3 H) 3.42-3.56 (m, 2 H) 3.41 (s, 3 H) 3.23 (s, 3 H) 3.15 (d, J=16.58 Hz, 1 H) 2.79 (d, J=16.58 Hz, 1 H) 1.48 (s, 3 H); LCMS for C23H24FN3O6S m/z 490.00 (M+H+).

Sources & evidence

ORD record
ord-c471b75cb0824ddabe1188a967609566
Source dataset
uspto-grants-2010_11
Patent number
US07842713B2

Reaction notes

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