Dichloromethane → HCID 59174916, compound

Participants

Reaction Steps

Dess-Martin periodinane (0.266 g, 0.627 mmol) was added to a solution of 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)ethanol (0.204 g, 0.522 mmol) in dichloromethane (15.00 mL, 0.522 mmol), and the reaction mixture was stirred at ambient temperature for 65 min. Saturated aqueous NaHCO3 was added and the reaction stirred for 5 min. The organic layer was dried and concentrated in vacuo, and purified by silica gel chromatography: ISCO 40 g column, 20-40% (3% Et3N in EtOAc)/hexanes to give 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)ethanone. MS (ESI) m/z: Calculated: 388.1; Observed: 389.0 (M++1).

Provenance & Evidence