5-(1-Phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-carboxylic acid → 5-(1-Phenylcyclopropyl)thiazolo[5,4-b]pyridine

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Reaction Steps

A solution of 5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-carboxylic acid (1.16 g, 3.91 mmol) in THF (78.0 mL) was stirred at 60° C. for 30 min. The reaction solution was then concentrated in vacuo, and the residue was chromatographically purified (silica gel, 0-45% EtOAc/Hexanes) to furnish 5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine as a light-yellow solid. MS (ESI) m/z: Calculated: 252.1; Observed: 253.0 (M++1).

Provenance & Evidence