4-Bromo-3-fluorotoluene → 2-(2-Fluoro-4-methylphenyl)-5-(1-phenylvinyl)thiazolo[5,4-b]pyridine

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Reaction Steps

Synthesized from 1-bromo-2-fluoro-4-methylbenzene (10 g, 53 mmol) and 2,6-dichloro-3-isothiocyanatopyridine (11 g, 53 mmol) according to the procedure for the synthesis of intermediate (2-(4-(1,3-dioxan-2-yl)-2-fluorophenyl)-5-(1-phenylvinyl)-thiazolo[5,4-b]pyridine) to give 2-(2-fluoro-4-methylphenyl)-5-(1-phenylvinyl)thiazolo[5,4-b]pyridine as a tan solid. MS (ESI) m/z: calculated: 346.1; Observed: 347.1 (M++1).

Provenance & Evidence