HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl azetidine-3-carboxylate hydrochloride → HCID 67111460, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl azetidine-3-carboxylate hydrochloride | HCID 21100040 | — |
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde | HCID 59174907 | — |
| Product | HCID 67111460 | HCID 67111460 | — |
Reaction Steps
Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)-benzaldehyde (1.3 g, 3.4 mmol) and methyl azetidine-3-carboxylate hydrochloride (0.77 g, 5.1 mmol) according to Reference R and the general procedure for reductive amination gave methyl 1-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)-azetidine-3-carboxylate as a light yellow solid. MS (ESI) m/z: Calculated: 473.2; Observed: 474.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-7de35176322d48859bc2be44f1b5f625 |
| Source note | uspto-grants-2010_11 |