Methyl pyrrolidine-3-carboxylate hydrochloride → HCID 67111608, compound

Participants

Reaction Steps

Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)-benzaldehyde (0.300 g, 0.801 mmol) and methylpyrrolidine-3-carboxylate hydrochloride (0.199 g, 1.20 mmol), according to Reference R and general procedure for reductive amination afforded the racemic mixture of methyl 1-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)pyrrolidine-3-carboxylate. MS (ESI) m/z: Calculated: 487.2; Observed: 488.0 (M++1). The enantiomers of methyl 1-((3-fluoro-4-(5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)pyrrolidine-3-carboxylate were separated by SFC chromatography (Column: Chiralpak AS-H (21×250 mm, 5 um); A: Liquid CO2; B: Isopropanol (0.2% DEA); Isocratic: 56:44 (A:B); Flow rate: 70 mL/min; Outlet Pressure: 100 bar) to give (R)-methyl 1-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)pyrrolidine-3-carboxylate and (S)-methyl 1-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)pyrrolidine-3-carboxylate.

Provenance & Evidence