反应详情

Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)-benzaldehyde (0.209 g, 0.56 mmol) and methyl 3-hydroxyazetidine-3-carboxylate acetate (0.14 g, 0.73 mmol) according to Reference R and general procedure for reductive amination afforded methyl 1-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)-methyl)-3-hydroxyazetidine-3-carboxylate. MS (ESI) m/z: Calculated: 489.2; Observed: 490.0 (M++1).