Methanol → Methyl 1-((3-fluoro-4-(5-(1-phenylcyclopentyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)azetidine-3-carboxylate

HRID 1177429Notes

Reaction equation

HRID 1177429 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:28][N:29]2[CH2:32][CH:31]([C:33]([O:35][CH3:36])=[O:34])[CH2:30]2)[CH:5]=[CH:6][C:7]=1[C:8]1[S:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[C:12]([C:17]1([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:21][CH:20]=[CH:19][CH2:18]1)[N:11]=2.O.CO>[Pd].C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([CH2:28][N:29]2[CH2:30][CH:31]([C:33]([O:35][CH3:36])=[O:34])[CH2:32]2)[CH:5]=[CH:6][C:7]=1[C:8]1[S:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[C:12]([C:17]1([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:21][CH2:20][CH2:19][CH2:18]1)[N:11]=2

Participants

6

Reactant 3

HCID 887MethanolHCID 962WaterHCID 67111616Methyl 1-((3-fluoro-4-(5-(1-phenylcyclopent-3-enyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)-methyl)azetidine-3-carboxylate

Product 1

HCID 67111568Methyl 1-((3-fluoro-4-(5-(1-phenylcyclopentyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)azetidine-3-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of methyl 1-((3-fluoro-4-(5-(1-phenylcyclopent-3-enyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)azetidine-3-carboxylate (0.333 g, 0.667 mmol) and 10% Pd/C, 50% water (0.355 g, 0.333 mmol) under nitrogen was added 5 mL MeOH and 5 mL THF. The resulting mixture was stirred rapidly under an H2 balloon for 4 h. The reaction mixture was flushed with nitrogen, filtered, rinsing with DCM, and concentrated in vacuo. The resulting oil was purified by silica gel chromatography, ISCO 0-100% EA/hexanes, to give methyl 1-((3-fluoro-4-(5-(1-phenylcyclopentyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)azetidine-3-carboxylate as a clear and colorless oil. MS (ESI) m/z: Calculated: 501.2; Observed: 502.1 (M++1).

Workup

  1. customThe reaction mixture was flushed with nitrogen
  2. filtrationfiltered
  3. washrinsing with DCM
  4. concentrationconcentrated in vacuo
  5. customThe resulting oil was purified by silica gel chromatography, ISCO 0-100% EA/hexanes

Sources & evidence

ORD record
ord-b8487c2686874184ab08f78c6b2e81a2
Source dataset
uspto-grants-2010_11
Patent number
US07842685B2

Reaction notes

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