Methyl azetidine-3-carboxylate hydrochloride → Methyl 1-((3-fluoro-4-(5-(1-phenylcyclohexyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)-methyl)azetidine-3-carboxylate

Participants

Reaction Steps

Reaction of 3-fluoro-4-(5-(1-phenylcyclohexyl)thiazolo[5,4-b]pyridine-2-yl)-benzaldehyde (0.36 g, 0.85 mmol), methyl azetidine-3-carboxylate hydrochloride (0.388 g, 2.56 mmol) according to Reference R and the general procedure for reductive amination to give methyl 1-((3-fluoro-4-(5-(1-phenylcyclohexyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)-methyl)azetidine-3-carboxylate as an oil which solidified to a white solid. MS (ESI) m/z: Calculated: 515.2; Observed: 516.1 (M++1).

Provenance & Evidence