Hydrochloric Acid → HCID 67111710, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of lithium hydroxide hydrate (66.4 mg, 1582 μmol) and methyl 1-((4-(5-benzoylthiazolo[5,4-b]pyridine-2-yl)-3-fluorophenyl)methyl)azetidine-3-carboxylate (233.0 mg, 505 μmol) in THF (12.6 mL) and water (1.7 mL) was stirred at 25° C. for 1.5 h. The reaction mixture was then diluted with water (1.0 mL), acidified with 1.0N HCl (1.58 mL), brought to pH 6 with 0.05M phosphate buffer (1.0 mL), and partially concentrated in vacuo. The resulting precipitate was collected by vacuum filtration, washed with water (3.0 mL), and dried in vacuo to afford 1-((4-(5-benzoylthiazolo[5,4-b]pyridine-2-yl)-3-fluorophenyl)methyl)-azetidine-3-carboxylic acid as a colorless solid. MS (ESI) m/z: Calculated: 447.1; Observed: 448.0 (M++1).

Provenance & Evidence