Tetrabutylammonium Fluoride → 2-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-6-(1-phenylcyclopropyl)-benzo[d]thiazole

Participants

Reaction Conditions

Reaction Steps

In a reactor bottle were combined 2-(4-(1,3-dioxan-2-yl)-2-fluorophenyl)-6-(1-phenyl-2-(trimethylsilyl)cyclopropyl)benzo[d]thiazole (1.305 g, 2.6 mmol) and neat tetrabutylammonium fluoride (25 mL, 25 mmol). The reaction mixture was heated to 110° C. in an oil bath and allowed to stir for 2 h. The mixture was cooled and extracted with EtOAc and water, dried over MgSO4 and concentrate in vacuo. Purification by silica gel chromatography afforded 2-(4-(1,3-dioxan-2-yl)-2-fluorophenyl)-6-(1-phenylcyclopropyl)-benzo[d]thiazole. MS (ESI) m/z: Calculated: 431.1; Observed: 432.1 (M++1).

Provenance & Evidence