HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycine methyl ester hydrochloride → Methyl 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzamido)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid | HCID 57394406 | — |
| Product | Methyl 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzamido)acetate | HCID 67112065 | — |
Reaction Steps
Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzoic acid (0.050 g, 0.13 mmol) and glycine methyl ester hydrochloride (0.019 g, 0.15 mmol), according to Reference S and the general procedure for amide formation afforded methyl 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzamido)acetate. MS (ESI) m/z: Calculated: 461.1; Observed: 462.0 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-149de2b455d8457e8d7cbaceeea98089 |
| Source note | uspto-grants-2010_11 |