HCID 67112004, compound → HCID 67111689, compound

Participants

Reaction Steps

A slurry of (E)-methyl 3-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)acrylate (0.116 g, 0.269 mmol) and Pd/C 10%, 50% water (0.115 g, 0.108 mmol) in 2 mL THF was treated with a hydrogen balloon with rapid stirring for 3 h. The reaction mixture was flushed with nitrogen, diluted with DCM, filtered through celite, rinsing with DCM. The filtrate was concentrated in vacuo to give methyl 3-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)propanoate as a white solid. MS (ESI) m/z; calculated: 432.1; Observed: 433.1 (M++1).

Provenance & Evidence