Sodium borohydride → HCID 44601272, compound

Participants

Reaction Steps

To a solution at 0° C. of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzaldehyde (2.00 g, 5.34 mmol) in THF (50 mL) and MeOH (25 mL) was added sodium borohydride (0.188 mL, 5.34 mmol). The reaction mixture was allowed to warm up to ambient temperature. The crude reaction mixture, after 1 h, was concentrated in vacuo and purified by silica gel chromatography to afford (3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methanol. MS (ESI) m/z: calculated: 376.1: Observed: 377.0 (M++1).

Provenance & Evidence