Carbon tetrabromide → HCID 67111838, compound

Participants

Reaction Steps

To a slurry of (3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methanol (2.05 g, 5.45 mmol), triphenylphosphine (1.64 mL, 7.08 mmol) in DCM (25 mL) at 0° C. under N2, carbon tetrabromide (0.634 mL, 6.53 mmol) was added. The reaction mixture was allowed to warm up to ambient temperature. The crude reaction mixture after 1 h, was concentrate in vacuo and purified by silica gel chromatography to afford 2-(4-(bromomethyl)-2-fluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine. MS (ESI) m/z; calculated: 438.0; Observed: 438.9 (M++1).

Provenance & Evidence